diff --git a/InvenTree/InvenTree/api_version.py b/InvenTree/InvenTree/api_version.py
index afcb7ea22e..7b003d9406 100644
--- a/InvenTree/InvenTree/api_version.py
+++ b/InvenTree/InvenTree/api_version.py
@@ -2,11 +2,14 @@
 
 
 # InvenTree API version
-INVENTREE_API_VERSION = 99
+INVENTREE_API_VERSION = 100
 
 """
 Increment this API version number whenever there is a significant change to the API that any clients need to know about
 
+v100 -> 2023-03-04 : https://github.com/inventree/InvenTree/pull/4452
+     - Adds bulk delete of PurchaseOrderLineItems to API
+
 v99 -> 2023-03-03 : https://github.com/inventree/InvenTree/pull/4445
     - Adds sort by "responsible" to PurchaseOrderAPI
 
diff --git a/InvenTree/order/api.py b/InvenTree/order/api.py
index 83ca354df1..b4a77fa34d 100644
--- a/InvenTree/order/api.py
+++ b/InvenTree/order/api.py
@@ -495,7 +495,7 @@ class PurchaseOrderLineItemFilter(rest_filters.FilterSet):
         return queryset
 
 
-class PurchaseOrderLineItemList(APIDownloadMixin, ListCreateAPI):
+class PurchaseOrderLineItemList(APIDownloadMixin, ListCreateDestroyAPIView):
     """API endpoint for accessing a list of PurchaseOrderLineItem objects.
 
     - GET: Return a list of PurchaseOrder Line Item objects
diff --git a/InvenTree/order/templates/order/purchase_order_detail.html b/InvenTree/order/templates/order/purchase_order_detail.html
index 914c97d6ab..a7cceb0d8a 100644
--- a/InvenTree/order/templates/order/purchase_order_detail.html
+++ b/InvenTree/order/templates/order/purchase_order_detail.html
@@ -38,6 +38,22 @@
     </div>
     <div class='panel-content'>
         <div id='order-toolbar-buttons' class='btn-group' style='float: right;'>
+            {% if roles.purchase_order.change %}
+            {% if order.is_pending or allow_extra_editing %}
+            <div class='btn-group' role='group'>
+                <!-- Multiple-select actions -->
+                <button id='multi-select-options' class='btn btn-primary dropdown-toggle' data-bs-toggle='dropdown'>
+                    <span class='fas fa-tools'></span> <span class='caret'></span>
+                </button>
+                <ul class='dropdown-menu'>
+                    <li><a class='dropdown-item' href='#' id='po-lines-bulk-delete' title='{% trans "Delete Line Items" %}'>
+                        <span class='fas fa-trash-alt icon-red'></span> {% trans "Delete Line Items" %}
+                    </a></li>
+                </ul>
+            </div>
+            {% endif %}
+            {% endif %}
+
             {% include "filter_list.html" with id="purchase-order-lines" %}
         </div>
 
diff --git a/InvenTree/order/test_api.py b/InvenTree/order/test_api.py
index f37937d7ce..976f198cad 100644
--- a/InvenTree/order/test_api.py
+++ b/InvenTree/order/test_api.py
@@ -603,6 +603,26 @@ class PurchaseOrderLineItemTest(OrderTest):
         self.filter({'has_pricing': 1}, 0)
         self.filter({'has_pricing': 0}, 5)
 
+    def test_po_line_bulk_delete(self):
+        """Test that we can bulk delete multiple PurchaseOrderLineItems via the API."""
+        n = models.PurchaseOrderLineItem.objects.count()
+
+        self.assignRole('purchase_order.delete')
+
+        url = reverse('api-po-line-list')
+
+        # Try to delete a set of line items via their IDs
+        self.delete(
+            url,
+            {
+                'items': [1, 2],
+            },
+            expected_code=204,
+        )
+
+        # We should have 2 less PurchaseOrderLineItems after deletign them
+        self.assertEqual(models.PurchaseOrderLineItem.objects.count(), n - 2)
+
 
 class PurchaseOrderDownloadTest(OrderTest):
     """Unit tests for downloading PurchaseOrder data via the API endpoint."""
diff --git a/InvenTree/templates/js/translated/order.js b/InvenTree/templates/js/translated/order.js
index 55b99f7d40..1ec8b48702 100644
--- a/InvenTree/templates/js/translated/order.js
+++ b/InvenTree/templates/js/translated/order.js
@@ -914,6 +914,7 @@ function poLineItemFields(options={}) {
                                 // Returned prices are in increasing order of quantity
                                 if (response.length > 0) {
                                     var idx = 0;
+                                    var index = 0;
 
                                     for (var idx = 0; idx < response.length; idx++) {
                                         if (response[idx].quantity > quantity) {
@@ -2213,6 +2214,71 @@ function loadPurchaseOrderTable(table, options) {
 }
 
 
+/*
+ * Delete the selected Purchase Order Line Items from the database
+ */
+function deletePurchaseOrderLineItems(items, options={}) {
+
+    function renderItem(item, opts={}) {
+
+        var part = item.part_detail;
+        var thumb = thumbnailImage(item.part_detail.thumbnail || item.part_detail.image);
+        var MPN = item.supplier_part_detail.manufacturer_part_detail ? item.supplier_part_detail.manufacturer_part_detail.MPN : '-';
+
+        var html = `
+        <tr>
+            <td>${thumb} ${part.full_name}</td>
+            <td>${part.description}</td>
+            <td>${item.supplier_part_detail.SKU}</td>
+            <td>${MPN}</td>
+            <td>${item.quantity}
+        </tr>
+        `;
+
+        return html;
+    }
+
+    var rows = '';
+    var ids = [];
+
+    items.forEach(function(item) {
+        rows += renderItem(item);
+        ids.push(item.pk);
+    });
+
+    var html = `
+    <div class='alert alert-block alert-danger'>
+    {% trans "All selected Line items will be deleted" %}
+    </div>
+
+    <table class='table table-striped table-condensed'>
+        <tr>
+            <th>{% trans "Part" %}</th>
+            <th>{% trans "Description" %}</th>
+            <th>{% trans "SKU" %}</th>
+            <th>{% trans "MPN" %}</th>
+            <th>{% trans "Quantity" %}</th>
+        </tr>
+        ${rows}
+    </table>
+    `;
+
+    constructForm('{% url "api-po-line-list" %}', {
+        method: 'DELETE',
+        multi_delete: true,
+        title: '{% trans "Delete selected Line items?" %}',
+        form_data: {
+            items: ids,
+        },
+        preFormContent: html,
+        onSuccess: function() {
+            // Refresh the table once the line items are deleted
+            $('#po-line-table').bootstrapTable('refresh');
+        },
+    });
+}
+
+
 /**
  * Load a table displaying line items for a particular PurchasesOrder
  * @param {String} table - HTML ID tag e.g. '#table'
@@ -2305,6 +2371,13 @@ function loadPurchaseOrderLineItemTable(table, options={}) {
                     }
                 });
             });
+
+            // Callback for bulk deleting mutliple lines
+            $('#po-lines-bulk-delete').off('click').on('click', function() {
+                var rows = getTableData('   #po-line-table');
+
+                deletePurchaseOrderLineItems(rows);
+            });
         }
 
         if (options.allow_receive) {
@@ -2569,6 +2642,13 @@ function loadPurchaseOrderLineItemTable(table, options={}) {
         ]
     });
 
+    linkButtonsToSelection(
+        table,
+        [
+            '#multi-select-options',
+        ]
+    );
+
 }