diff --git a/src/backend/InvenTree/InvenTree/apps.py b/src/backend/InvenTree/InvenTree/apps.py
index 34f74850a3..afb372614c 100644
--- a/src/backend/InvenTree/InvenTree/apps.py
+++ b/src/backend/InvenTree/InvenTree/apps.py
@@ -320,6 +320,11 @@ class InvenTreeConfig(AppConfig):
         if MIGRATIONS_CHECK_DONE:
             return
 
+        # Exit early if we are not in a state where we can access the database,
+        # otherwise we might end up in a deadlock situation
+        if not InvenTree.ready.canAppAccessDatabase():
+            return
+
         if not InvenTree.tasks.check_for_migrations():
             logger.error('INVE-W8: Database Migrations required')
             sys.exit(1)
diff --git a/src/backend/InvenTree/InvenTree/tasks.py b/src/backend/InvenTree/InvenTree/tasks.py
index 123ee4f966..531b2ace19 100644
--- a/src/backend/InvenTree/InvenTree/tasks.py
+++ b/src/backend/InvenTree/InvenTree/tasks.py
@@ -586,6 +586,12 @@ def update_exchange_rates(force: bool = False):
     Arguments:
         force: If True, force the update to run regardless of the last update time
     """
+    from InvenTree.ready import canAppAccessDatabase
+
+    # Do not update exchange rates if we cannot access the database
+    if not canAppAccessDatabase(allow_test=True, allow_shell=True):
+        return
+
     try:
         from djmoney.contrib.exchange.models import Rate
 
diff --git a/src/backend/InvenTree/common/settings.py b/src/backend/InvenTree/common/settings.py
index c721d8c346..d1d8763461 100644
--- a/src/backend/InvenTree/common/settings.py
+++ b/src/backend/InvenTree/common/settings.py
@@ -44,6 +44,13 @@ def get_global_setting(key, backup_value=None, environment_key=None, **kwargs):
 def set_global_setting(key, value, change_user=None, create=True, **kwargs):
     """Set the value of a global setting using the provided key."""
     from common.models import InvenTreeSetting
+    from InvenTree.ready import canAppAccessDatabase
+
+    if not canAppAccessDatabase(allow_shell=True, allow_test=True):
+        logger.warning(
+            f'Cannot set global setting "{key}" - database is not accessible'
+        )
+        return False
 
     kwargs['change_user'] = change_user
     kwargs['create'] = create