diff --git a/CHANGELOG.md b/CHANGELOG.md
index 6ddf14e18d..3a589a23d8 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -13,6 +13,8 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 ### Changed
 
+- Changed site URL check to allow protocol mismatches if `INVENTREE_SITE_LAX_PROTOCOL` is set to `True` (default) in [#10454](https://github.com/inventree/InvenTree/pull/10454)
+
 ### Removed
 
 
diff --git a/docs/docs/start/config.md b/docs/docs/start/config.md
index bb1523a3f8..c151bf6a32 100644
--- a/docs/docs/start/config.md
+++ b/docs/docs/start/config.md
@@ -135,6 +135,7 @@ Depending on how your InvenTree installation is configured, you will need to pay
 | INVENTREE_CORS_ORIGIN_WHITELIST | cors.whitelist | List of whitelisted CORS URLs. Refer to the [django-cors-headers documentation](https://github.com/adamchainz/django-cors-headers#cors_allowed_origins-sequencestr) | Uses the *INVENTREE_SITE_URL* parameter, if set. Otherwise, an empty list. |
 | INVENTREE_CORS_ORIGIN_REGEX | cors.regex | List of regular expressions for CORS whitelisted URL patterns | *Empty list* |
 | INVENTREE_CORS_ALLOW_CREDENTIALS | cors.allow_credentials | Allow cookies in cross-site requests | `True` |
+| INVENTREE_SITE_LAX_PROTOCOL | site_lax_protocol | Ignore protocol mismatches on INVE-E7 site checks | `True` |
 | INVENTREE_USE_X_FORWARDED_HOST | use_x_forwarded_host | Use forwarded host header | `False` |
 | INVENTREE_USE_X_FORWARDED_PORT | use_x_forwarded_port | Use forwarded port header | `False` |
 | INVENTREE_USE_X_FORWARDED_PROTO | use_x_forwarded_proto | Use forwarded protocol header | `False` |
diff --git a/src/backend/InvenTree/InvenTree/middleware.py b/src/backend/InvenTree/InvenTree/middleware.py
index 4bfb0ace37..a886aa3eac 100644
--- a/src/backend/InvenTree/InvenTree/middleware.py
+++ b/src/backend/InvenTree/InvenTree/middleware.py
@@ -234,9 +234,17 @@ class InvenTreeHostSettingsMiddleware(MiddlewareMixin):
         if path in urls or any(path.startswith(p) for p in paths_ignore):
             return None
 
-        # Ensure that the settings are set correctly with the current request
+        # treat the accessed scheme and host
         accessed_scheme = request._current_scheme_host
-        if accessed_scheme and not accessed_scheme.startswith(settings.SITE_URL):
+        referer = urlsplit(accessed_scheme)
+
+        # Ensure that the settings are set correctly with the current request
+        matches = (
+            (accessed_scheme and not accessed_scheme.startswith(settings.SITE_URL))
+            if not settings.SITE_LAX_PROTOCOL_CHECK
+            else not is_same_domain(referer.netloc, urlsplit(settings.SITE_URL).netloc)
+        )
+        if matches:
             if (
                 isinstance(settings.CSRF_TRUSTED_ORIGINS, list)
                 and len(settings.CSRF_TRUSTED_ORIGINS) > 1
@@ -251,7 +259,6 @@ class InvenTreeHostSettingsMiddleware(MiddlewareMixin):
                 )
 
         # Check trusted origins
-        referer = urlsplit(accessed_scheme)
         if not any(
             is_same_domain(referer.netloc, host)
             for host in [
diff --git a/src/backend/InvenTree/InvenTree/settings.py b/src/backend/InvenTree/InvenTree/settings.py
index e5a3f4297e..25ae289a4c 100644
--- a/src/backend/InvenTree/InvenTree/settings.py
+++ b/src/backend/InvenTree/InvenTree/settings.py
@@ -1064,6 +1064,9 @@ DATE_INPUT_FORMATS = ['%Y-%m-%d']
 
 # Site URL can be specified statically, or via a run-time setting
 SITE_URL = get_setting('INVENTREE_SITE_URL', 'site_url', None)
+SITE_LAX_PROTOCOL_CHECK = get_boolean_setting(
+    'INVENTREE_SITE_LAX_PROTOCOL', 'site_lax_protocol', True
+)
 
 if SITE_URL:
     SITE_URL = str(SITE_URL).strip().rstrip('/')
diff --git a/src/backend/InvenTree/InvenTree/test_middleware.py b/src/backend/InvenTree/InvenTree/test_middleware.py
index f308d0526d..5793d9949d 100644
--- a/src/backend/InvenTree/InvenTree/test_middleware.py
+++ b/src/backend/InvenTree/InvenTree/test_middleware.py
@@ -110,6 +110,24 @@ class MiddlewareTests(InvenTreeTestCase):
             response = self.client.get(reverse('web'))
             self.do_positive_test(response)
 
+    def test_site_lax_protocol(self):
+        """Test that the site URL check is correctly working with/without lax protocol check."""
+        # Simple setup with proxy
+        with self.settings(
+            SITE_URL='https://testserver', CSRF_TRUSTED_ORIGINS=['https://testserver']
+        ):
+            response = self.client.get(reverse('web'))
+            self.do_positive_test(response)
+
+        # No worky if strong security
+        with self.settings(
+            SITE_URL='https://testserver',
+            CSRF_TRUSTED_ORIGINS=['https://testserver'],
+            SITE_LAX_PROTOCOL_CHECK=False,
+        ):
+            response = self.client.get(reverse('web'))
+            self.assertContains(response, 'INVE-E7: The used path', status_code=500)
+
     def test_site_url_checks_multi(self):
         """Test that the site URL check is correctly working in a multi-site setup."""
         # multi-site setup with trusted origins
@@ -162,7 +180,6 @@ class MiddlewareTests(InvenTreeTestCase):
             CSRF_TRUSTED_ORIGINS=['https://example.com'],
         ):
             response = self.client.get(reverse('web'))
-            self.assertEqual(response.status_code, 500)
             self.assertContains(
                 response, 'is not in the TRUSTED_ORIGINS', status_code=500
             )
@@ -176,7 +193,6 @@ class MiddlewareTests(InvenTreeTestCase):
             CSRF_TRUSTED_ORIGINS=['http://localhost:8000'],
         ):
             response = self.client.get(reverse('web'))
-            self.assertEqual(response.status_code, 500)
             self.assertContains(
                 response, 'INVE-E7: The used path `http://testserver` ', status_code=500
             )