diff --git a/InvenTree/InvenTree/helpers.py b/InvenTree/InvenTree/helpers.py
index c5a8ad4b67..7bd4fd819d 100644
--- a/InvenTree/InvenTree/helpers.py
+++ b/InvenTree/InvenTree/helpers.py
@@ -427,8 +427,9 @@ def extract_serial_numbers(serials, expected_quantity, next_number: int):
     serials = serials.strip()
 
     # fill in the next serial number into the serial
-    if '~' in serials:
-        serials = serials.replace('~', str(next_number))
+    while '~' in serials:
+        serials = serials.replace('~', str(next_number), 1)
+        next_number += 1
 
     # Split input string by whitespace or comma (,) characters
     groups = re.split("[\s,]+", serials)
@@ -438,6 +439,12 @@ def extract_serial_numbers(serials, expected_quantity, next_number: int):
 
     # Helper function to check for duplicated numbers
     def add_sn(sn):
+        # Attempt integer conversion first, so numerical strings are never stored
+        try:
+            sn = int(sn)
+        except ValueError:
+            pass
+
         if sn in numbers:
             errors.append(_('Duplicate serial: {sn}').format(sn=sn))
         else:
@@ -451,15 +458,25 @@ def extract_serial_numbers(serials, expected_quantity, next_number: int):
     if len(serials) == 0:
         raise ValidationError([_("Empty serial number string")])
 
-    for group in groups:
+    # If the user has supplied the correct number of serials, don't process them for groups
+    # just add them so any duplicates (or future validations) are checked
+    if len(groups) == expected_quantity:
+        for group in groups:
+            add_sn(group)
 
+        if len(errors) > 0:
+            raise ValidationError(errors)
+
+        return numbers
+
+    for group in groups:
         group = group.strip()
 
         # Hyphen indicates a range of numbers
         if '-' in group:
             items = group.split('-')
 
-            if len(items) == 2:
+            if len(items) == 2 and all([i.isnumeric() for i in items]):
                 a = items[0].strip()
                 b = items[1].strip()
 
@@ -471,13 +488,14 @@ def extract_serial_numbers(serials, expected_quantity, next_number: int):
                         for n in range(a, b + 1):
                             add_sn(n)
                     else:
-                        errors.append(_("Invalid group: {g}").format(g=group))
+                        errors.append(_("Invalid group range: {g}").format(g=group))
 
                 except ValueError:
                     errors.append(_("Invalid group: {g}").format(g=group))
                     continue
             else:
-                errors.append(_("Invalid group: {g}").format(g=group))
+                # More than 2 hyphens or non-numeric group so add without interpolating
+                add_sn(group)
 
         # plus signals either
         # 1:  'start+':  expected number of serials, starting at start
@@ -495,23 +513,17 @@ def extract_serial_numbers(serials, expected_quantity, next_number: int):
 
                 # case 1
                 else:
-                    end = start + expected_quantity
+                    end = start + (expected_quantity - len(numbers))
 
                 for n in range(start, end):
                     add_sn(n)
             # no case
             else:
-                errors.append(_("Invalid group: {g}").format(g=group))
+                errors.append(_("Invalid group sequence: {g}").format(g=group))
 
         # At this point, we assume that the "group" is just a single serial value
         elif group:
-
-            try:
-                # First attempt to add as an integer value
-                add_sn(int(group))
-            except (ValueError):
-                # As a backup, add as a string value
-                add_sn(group)
+            add_sn(group)
 
         # No valid input group detected
         else:
diff --git a/InvenTree/InvenTree/tests.py b/InvenTree/InvenTree/tests.py
index 669628bdea..13f9198d92 100644
--- a/InvenTree/InvenTree/tests.py
+++ b/InvenTree/InvenTree/tests.py
@@ -252,6 +252,31 @@ class TestSerialNumberExtraction(TestCase):
         sn = e("1, 2, 3, 4, 5", 5, 1)
         self.assertEqual(len(sn), 5)
 
+        # Test partially specifying serials
+        sn = e("1, 2, 4+", 5, 1)
+        self.assertEqual(len(sn), 5)
+        self.assertEqual(sn, [1, 2, 4, 5, 6])
+
+        # Test groups are not interpolated if enough serials are supplied
+        sn = e("1, 2, 3, AF5-69H, 5", 5, 1)
+        self.assertEqual(len(sn), 5)
+        self.assertEqual(sn, [1, 2, 3, "AF5-69H", 5])
+
+        # Test groups are not interpolated with more than one hyphen in a word
+        sn = e("1, 2, TG-4SR-92, 4+", 5, 1)
+        self.assertEqual(len(sn), 5)
+        self.assertEqual(sn, [1, 2, "TG-4SR-92", 4, 5])
+
+        # Test groups are not interpolated with alpha characters
+        sn = e("1, A-2, 3+", 5, 1)
+        self.assertEqual(len(sn), 5)
+        self.assertEqual(sn, [1, "A-2", 3, 4, 5])
+
+        # Test multiple placeholders
+        sn = e("1 2 ~ ~ ~", 5, 3)
+        self.assertEqual(len(sn), 5)
+        self.assertEqual(sn, [1, 2, 3, 4, 5])
+
         sn = e("1-5, 10-15", 11, 1)
         self.assertIn(3, sn)
         self.assertIn(13, sn)
@@ -307,6 +332,10 @@ class TestSerialNumberExtraction(TestCase):
         with self.assertRaises(ValidationError):
             e("10, a, 7-70j", 4, 1)
 
+        # Test groups are not interpolated with word characters
+        with self.assertRaises(ValidationError):
+            e("1, 2, 3, E-5", 5, 1)
+
     def test_combinations(self):
         e = helpers.extract_serial_numbers