diff --git a/src/backend/InvenTree/InvenTree/fields.py b/src/backend/InvenTree/InvenTree/fields.py
index b7c09dbe12..1254b1b57d 100644
--- a/src/backend/InvenTree/InvenTree/fields.py
+++ b/src/backend/InvenTree/InvenTree/fields.py
@@ -1,6 +1,7 @@
 """Custom fields used in InvenTree."""
 
 import sys
+import uuid
 from decimal import Decimal
 
 from django import forms
@@ -59,6 +60,34 @@ class InvenTreeURLField(models.URLField):
         super().__init__(**kwargs)
 
 
+class InvenTreeUUIDField(models.UUIDField):
+    """UUIDField which is always stored as a char(32) column on MySQL / MariaDB.
+
+    On MariaDB 10.7+, Django maps UUIDField to the native 'uuid' column type,
+    and writes 36-character (hyphenated) values to match.
+    However, databases migrated under older Django / MariaDB versions retain
+    their original char(32) columns, into which a 36-character value does not fit.
+
+    To ensure consistent behavior across all supported database backends,
+    we force the legacy char(32) storage format on MySQL / MariaDB.
+
+    Ref: https://docs.djangoproject.com/en/5.2/releases/5.0/#migrating-existing-uuidfield-on-mariadb-10-7
+    """
+
+    def db_type(self, connection):
+        """Force a char(32) column type on MySQL / MariaDB backends."""
+        if connection.vendor == 'mysql':
+            return 'char(32)'
+        return super().db_type(connection)
+
+    def get_db_prep_value(self, value, connection, prepared=False):
+        """Store values in 32-character hex format on MySQL / MariaDB backends."""
+        value = super().get_db_prep_value(value, connection, prepared)
+        if connection.vendor == 'mysql' and isinstance(value, uuid.UUID):
+            value = value.hex
+        return value
+
+
 def money_kwargs(**kwargs):
     """Returns the database settings for MoneyFields."""
     from common.currency import currency_code_mappings
diff --git a/src/backend/InvenTree/common/migrations/0046_alter_emailmessage_global_id_and_more.py b/src/backend/InvenTree/common/migrations/0046_alter_emailmessage_global_id_and_more.py
new file mode 100644
index 0000000000..5ead5a53bf
--- /dev/null
+++ b/src/backend/InvenTree/common/migrations/0046_alter_emailmessage_global_id_and_more.py
@@ -0,0 +1,59 @@
+"""Migration to store UUID primary keys as char(32) on MySQL / MariaDB.
+
+On MariaDB 10.7+, Django 5.x creates UUIDField columns with the native 'uuid'
+type and writes 36-character (hyphenated) values. Databases migrated under older
+Django / MariaDB versions retain char(32) columns, into which the new values
+do not fit.
+
+See: https://github.com/inventree/InvenTree/issues/12270
+"""
+
+import uuid
+
+from django.db import migrations
+
+import InvenTree.fields
+
+
+class Migration(migrations.Migration):
+    dependencies = [('common', '0045_projectcode_active')]
+
+    operations = [
+        migrations.AlterField(
+            model_name='emailmessage',
+            name='global_id',
+            field=InvenTree.fields.InvenTreeUUIDField(
+                default=uuid.uuid4,
+                editable=False,
+                help_text='Unique identifier for this message',
+                primary_key=True,
+                serialize=False,
+                unique=True,
+                verbose_name='Global ID',
+            ),
+        ),
+        migrations.AlterField(
+            model_name='emailthread',
+            name='global_id',
+            field=InvenTree.fields.InvenTreeUUIDField(
+                default=uuid.uuid4,
+                editable=False,
+                help_text='Unique identifier for this thread',
+                primary_key=True,
+                serialize=False,
+                verbose_name='Global ID',
+            ),
+        ),
+        migrations.AlterField(
+            model_name='webhookmessage',
+            name='message_id',
+            field=InvenTree.fields.InvenTreeUUIDField(
+                default=uuid.uuid4,
+                editable=False,
+                help_text='Unique identifier for this message',
+                primary_key=True,
+                serialize=False,
+                verbose_name='Message ID',
+            ),
+        ),
+    ]
diff --git a/src/backend/InvenTree/common/models.py b/src/backend/InvenTree/common/models.py
index b07dd08eeb..bb89a0622b 100644
--- a/src/backend/InvenTree/common/models.py
+++ b/src/backend/InvenTree/common/models.py
@@ -1584,7 +1584,7 @@ class WebhookMessage(models.Model):
         worked_on: Was the work on this message finished?
     """
 
-    message_id = models.UUIDField(
+    message_id = InvenTree.fields.InvenTreeUUIDField(
         verbose_name=_('Message ID'),
         help_text=_('Unique identifier for this message'),
         primary_key=True,
@@ -3266,7 +3266,7 @@ class EmailMessage(models.Model):
         TRACK_READ = 'track_read', _('Track Read')
         TRACK_CLICK = 'track_click', _('Track Click')
 
-    global_id = models.UUIDField(
+    global_id = InvenTree.fields.InvenTreeUUIDField(
         verbose_name=_('Global ID'),
         help_text=_('Unique identifier for this message'),
         primary_key=True,
@@ -3374,7 +3374,7 @@ class EmailThread(InvenTree.models.InvenTreeMetadataModel):
         blank=True,
         help_text=_('Unique key for this thread (used to identify the thread)'),
     )
-    global_id = models.UUIDField(
+    global_id = InvenTree.fields.InvenTreeUUIDField(
         verbose_name=_('Global ID'),
         help_text=_('Unique identifier for this thread'),
         primary_key=True,
diff --git a/src/backend/InvenTree/machine/migrations/0002_alter_machineconfig_id.py b/src/backend/InvenTree/machine/migrations/0002_alter_machineconfig_id.py
new file mode 100644
index 0000000000..5d3aac8bea
--- /dev/null
+++ b/src/backend/InvenTree/machine/migrations/0002_alter_machineconfig_id.py
@@ -0,0 +1,28 @@
+"""Migration to store MachineConfig UUID primary keys as char(32) on MySQL / MariaDB.
+
+On MariaDB 10.7+, Django 5.x writes 36-character (hyphenated) UUID values,
+but databases migrated under older Django / MariaDB versions retain char(32)
+columns, causing machine creation to fail with "Data too long for column 'id'".
+
+See: https://github.com/inventree/InvenTree/issues/12270
+"""
+
+import uuid
+
+from django.db import migrations
+
+import InvenTree.fields
+
+
+class Migration(migrations.Migration):
+    dependencies = [('machine', '0001_initial')]
+
+    operations = [
+        migrations.AlterField(
+            model_name='machineconfig',
+            name='id',
+            field=InvenTree.fields.InvenTreeUUIDField(
+                default=uuid.uuid4, editable=False, primary_key=True, serialize=False
+            ),
+        ),
+    ]
diff --git a/src/backend/InvenTree/machine/models.py b/src/backend/InvenTree/machine/models.py
index b81b1c7a00..f1f1896a85 100755
--- a/src/backend/InvenTree/machine/models.py
+++ b/src/backend/InvenTree/machine/models.py
@@ -10,6 +10,7 @@ from django.utils.safestring import mark_safe
 from django.utils.translation import gettext_lazy as _
 
 import common.models
+import InvenTree.fields
 from machine import registry
 from machine.machine_type import BaseMachineType
 
@@ -17,7 +18,9 @@ from machine.machine_type import BaseMachineType
 class MachineConfig(models.Model):
     """A Machine objects represents a physical machine."""
 
-    id = models.UUIDField(primary_key=True, default=uuid.uuid4, editable=False)
+    id = InvenTree.fields.InvenTreeUUIDField(
+        primary_key=True, default=uuid.uuid4, editable=False
+    )
 
     name = models.CharField(
         unique=True,